Characterising and Evaluating the Immune Microenvironment Landscapes of Colorectal Cancer Shaped by Different Therapies.

ABSTRACT: Colorectal cancer (CRC) occurs as the third most common cancer with high mortality across the world. Understanding the intratumoral immune cell heterogeneity and their responses to various therapies is crucial for enhancing patient outcomes. This study aimed to characterise and evaluate the immune microenvironment landscapes of CRC shaped by different therapies including CD73 inhibitor, PD-1 blockade and photothermal therapy (PTT). Our investigation revealed that three therapies could commonly modulate the down-regulation of Treg, M2 macrophage and Ptprj+ G4 granulocyte, up-regulation of effector/memory T cell, M1 macorphage and Hilpda+ G1 granulocyte. Moreover, we identified the uniquely dis-regulated cell types and pathway activities response to each therapy, such as CD73 inhibitor enric

SUBMITTER: Zhou C 

PROVIDER: S-EPMC12266622 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature