Efficiency loss with binary pre-processing of continuous monitoring data.

ABSTRACT: In studies with a recurrent event outcome, events may be captured as counts during subsequent intervals or follow-up times either by design or for ease of analysis. In many cases, recurrent events may be further coarsened such that only an indicator of one or more events in an interval is observed at the follow-up time, resulting in a loss of information relative to a record of all events. In this paper, we examine efficiency loss when coarsening longitudinally observed counts to binary indicators and aspects of the design which impact the ability to estimate a treatment effect of interest. The investigation was motivated by a study of patients with cardiac implantable electronic devices in which investigators aimed to examine the effect of a treatment on events detected by the devices ove

SUBMITTER: Langner PR 

PROVIDER: S-EPMC12266715 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature