Single neurons and networks in the mouse claustrum integrate input from widespread cortical sources.

ABSTRACT: The claustrum is thought to be one of the most highly interconnected forebrain structures, but its organizing principles have yet to be fully explored at the level of single neurons. Here, we investigated the identity, connectivity, and activity of identified claustrum neurons in Mus musculus to understand how the structure's unique convergence of input and divergence of output support binding information streams. We found that neurons in the claustrum communicate with each other across efferent projection-defined modules which were differentially innervated by sensory and frontal cortical areas. Individual claustrum neurons were responsive to inputs from more than one cortical region in a cell-type and projection-specific manner, particularly between areas of frontal cortex. In viv

SUBMITTER: Shelton AM 

PROVIDER: S-EPMC12266724 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature