Physical Activity Modifies the Metabolic Profile of CD4⁺ and CD8⁺ T-Cell Subtypes at Rest and Upon Activation in Older Adults.

ABSTRACT: T-cell metabolism is a key regulator of immune function. Metabolic dysfunction in T cells from young mice results in an aged phenotype, accelerating immunosenescence. Physical activity (PA) maintains T-cell function and delays immunosenescence in older adults, but the underlying mechanisms are poorly understood. We investigated the effects of PA on the metabolic and functional profiles at a single-cell resolution of resting and stimulated T cells from young adults (N = 9, 23 ± 3 years) and physically active older adults clustered between higher PA (HPA, N = 9, 75.5 ± 4.7 years) or lower PA levels (LPA, N = 10, 76.4 ± 2.1 years). Compared to young donors, HPA older adults had higher mitochondrial dependence (MD) and lower glucose dependence (GD) in unstimulated naïve, central memory (CM) an

SUBMITTER: Hazeldine J 

PROVIDER: S-EPMC12266771 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature