Aged Gut Microbiota Contributes to Cognitive Impairment and Hippocampal Synapse Loss in Mice.

ABSTRACT: Gut microbiota alteration during the aging process serves as a causative factor for aging-related cognitive decline, which is characterized by the early hallmark, hippocampal synaptic loss. However, the impact and mechanistic role of gut microbiota in hippocampal synapse loss during aging remains unclear. Here, we observed that the fecal microbiota of naturally aged mice successfully transferred cognitive impairment and hippocampal synapse loss to young recipients. Multi-omics analysis revealed that aged gut microbiota was characterized with obvious change in Bifidobacterium pseudolongum (B.p) and metabolite of tryptophan, indoleacetic acid (IAA) in the periphery and brain. These features were also reproduced in young recipients that were transplanted with aged gut microbiota. Fecal B.p ab

SUBMITTER: Li M 

PROVIDER: S-EPMC12266779 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature