TLR7 Mediates HIV-1 Tat-Induced Cellular Senescence in Human Astrocytes.

ABSTRACT: Cellular senescence contributes to accelerated aging, neuroinflammation, and the development of HIV-associated neurocognitive disorders (HAND) in the era of combined antiretroviral therapy (cART). One HIV viral factor that could lead to cellular senescence is the persistence of HIV-1 Tat in the brain. As a secreted viral protein, Tat is known to enter endolysosomes of cells through receptor-mediated endocytosis, and we have shown that Tat induces endolysosome damage and dysfunction. Significantly, endolysosome dysfunction has been strongly linked to cellular senescence. However, it is not known whether endolysosome dysfunction represents a driver or consequence of cellular senescence. Because Tat-induced endolysosome damage represents an early step in exogenous Tat-induced cellular senesce

SUBMITTER: Rezagholizadeh N 

PROVIDER: S-EPMC12266786 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature