The lifetime accumulation of multimorbidity and its influence on dementia risk: a UK Biobank study.

ABSTRACT: The number of people living with dementia worldwide is projected to reach 150 million by 2050, making prevention a crucial priority for health services. The co-occurrence of two or more chronic health conditions, termed multimorbidity, occurs in up to 80% of dementia patients, making multimorbidity an important risk factor for dementia. However, we lack an understanding of the specific health conditions, and their age of onset, that drive the link between multimorbidity and dementia. Using data from 282 712 participants of the UK Biobank, we defined the sequential patterns of accumulation of 46 chronic conditions over the life course. By grouping individuals based on their life history of chronic illness, we show here that the risk of incident dementia can be stratified by both the type an

SUBMITTER: Patel R 

PROVIDER: S-EPMC12266833 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature