Association between non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio and the risk of gestational diabetes: a retrospective study.

ABSTRACT:

Background

Previous studies have shown an association between non-high-density lipoprotein cholesterol (non-HDL-C)-to-HDL-C ratio (NHHR) and diabetes; however, its impact on pregnant women remains unclear. This study aims to explore the association between NHHR in early to mid-pregnancy and the incidence of gestational diabetes mellitus (GDM).

Methods

This study retrospectively collected and analyzed prenatal examination data from pregnant women. Variables were selected using least absolute shrinkage and selection operator (LASSO) regression and multivariable logistic regression, and the association between NHHR and GDM incidence was assessed through sensitivity and subgroup analyses. Propensity score matching (PSM) was applied to reduce selection bias between groups. Additi

SUBMITTER: Li G 

PROVIDER: S-EPMC12267022 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature