Association between gestational diabetes mellitus and risk of breast cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

Gestational diabetes mellitus (GDM), a prevalent metabolic complication during pregnancy, has a global prevalence of approximately 14%. Its onset is closely associated with insulin resistance, insufficient compensatory function of β - cells, and abnormal placental function. Epidemiological studies have indicated that type 2 diabetes is an independent risk factor for breast cancer. However, the association between GDM and the risk of breast cancer remains controversial.

Objective

This systematic review and meta-analysis aim to comprehensively evaluate the association between GDM and the risk of breast cancer and explore its underlying mechanisms.

Methods

This study systematically searched PubMed, Web of Science, Scopus, EMBASE, and the Cochrane Library datab

SUBMITTER: Li J 

PROVIDER: S-EPMC12267041 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature