Clinical and Genomic Features of Classical and Basal Transcriptional Subtypes in Pancreatic Cancer.

ABSTRACT:

Purpose

Transcriptional profiling of pancreatic cancers has defined two main transcriptional subtypes: classical and basal. Initial data suggest shorter survival for patients with basal tumors and differing treatment sensitivity to FOLFIRINOX and gemcitabine plus nab-paclitaxel by transcriptional subtype.

Experimental design

We examined 8,743 patients with RNA sequencing from pancreatic cancers performed at Caris Life Sciences. Classical and basal subtypes were identified using purity independent subtyping algorithm on RNA sequencing, and two cohorts were analyzed: (i) the biomarker cohort included patients with complete molecular profiling data (n = 7,250) and (ii) the outcome cohort included patients with metastatic disease with available survival outcomes (n = 5,335). A t

SUBMITTER: Singh H 

PROVIDER: S-EPMC12267046 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature