Efficacy and Safety of Mycophenolate Mofetil Compared to Azathioprine in Autoimmune Hepatitis: A Meta-Analysis.

ABSTRACT:

Background

Mycophenolate mofetil (MMF) has been suggested as a potential alternative treatment option for patients who are intolerant or unresponsive to the standard corticosteroid and azathioprine (AZA) regimen for autoimmune hepatitis (AIH). This systematic review and meta-analysis aimed to comprehensively evaluate and compare the biochemical efficacy and safety profiles of MMF and AZA in the treatment of AIH.

Methods

This review systematically examined the available literature from the inception of the MEDLINE and EMBASE databases up to November 2024. The primary outcomes of interest included the evaluation of biochemical remission (BR), the effectiveness of MMF in patients who were non-responsive (AZA-NR) or intolerant to azathioprine (AZA-IT), and the assessment of adve

SUBMITTER: Khan S 

PROVIDER: S-EPMC12267078 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature