Allotype-Dependent Responses to the Vaccine Candidate Thrombospondin-Like Protein of Dictyocaulus viviparus in Calves.

ABSTRACT: The nematode Dictyocaulus viviparus causes parasitic bronchitis in cattle. There is a vaccine based on irradiated larvae against this parasite. However, no memory response is induced, and donor calves are needed for culturing the larvae. Therefore, a well-defined subunit vaccine would be welcomed. Because thrombospondin-like protein (TLP) is an immunodominant protein from the brush border of adult parasites, it was tested as a vaccine candidate. Calves (n = 7) were vaccinated twice with TLP in Quil-A, and antibody responses, IgG2 allotypes and protection were determined. Protection is defined here as decreased worm counts from challenge infection compared with age-matched control calves (N = 7). Only 27% protection (not significant) was found in the vaccinated calves. However, strong IgG a

SUBMITTER: Kooyman FNJ 

PROVIDER: S-EPMC12267107 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature