A comprehensive analysis of the inherited lncRNA and circRNA repertoire of zebrafish.

ABSTRACT:

Motivation

Inherited non-coding RNAs can be the third major component of epigenetic information transfer from one generation to the next. Here, we present a comprehensive resource of lncRNAs and circular RNAs that are inherited, compiled from meta-analysis of zebrafish transcriptomics data and comparative genomics with mouse and human. Maternal and paternal inheritance of mRNA into the zygote is accepted to be an important regulator of embryonic development as well as adult characteristics. Although inheritance of certain specific miRNAs is known, other non-coding RNA inheritance remains less explored.

Results

We performed a comprehensive analysis of the inherited lncRNAs and circRNAs in zebrafish. We discovered that nearly 20% of all known lncRNA and 7% of circRNAs are inhe

SUBMITTER: Joshi DC 

PROVIDER: S-EPMC12267137 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature