Relationship between tau-PET and quantitative susceptibility mapping in atypical Alzheimer's disease.

ABSTRACT:

Background

Iron is an important component in neurofibrillary tangles, is known to co-localize with tangles in Alzheimer's disease (AD) and can be measured using quantitative susceptibility mapping (QSM). However, it is unclear if iron measured using QSM is regionally related to tau in atypical presentations of AD.

Methods

Forty patients with atypical AD underwent a 3 T magnetic resonance imaging (MRI) scan with a five-echo gradient echo sequence to calculate QSM, Aβ, and [¹⁸F] AV-1451 positron emission tomography (PET). The relationship between QSM and tau-PET was assessed using voxel-based regression analysis using whole brain VoxelStats and region-of-interest (ROI)-based Spearman's correlation analyses using cortical and subcortical ROIs.

Results

At the v

SUBMITTER: Singh-Reilly N 

PROVIDER: S-EPMC12267165 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature