Immunomodulatory effects of atorvastatin on peripheral blood mononuclear cells infected with <i>Mycobacterium tuberculosis</i>.

ABSTRACT:

Background

Tuberculosis (TB) remains a major global health threat, contributing substantially to high morbidity and mortality rates. This underscores the urgent need for more effective interventions. Recent studies highlight the potential of host-directed therapy approaches to enhance immune defences against TB. Atorvastatin, recognized for both its lipid-lowering properties and its immunomodulatory effects, has emerged as a compelling candidate for host-directed therapy against TB. Here, we investigated the ex vivo efficacy of atorvastatin in inducing immunomodulatory activities (phagosome maturation, autophagy, and apoptosis) and enhancing the mycobacterial killing capacity in Mycobacterium tuberculosis (Mtb)-infected peripheral blood mononuclear cells (PBMCs

SUBMITTER: Sabeel S 

PROVIDER: S-EPMC12267233 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature