Gait dynamics and brain function abnormalities in Parkinson's disease with freezing of gait: a clinical study using resting-state fMRI and wearable devices.

ABSTRACT:

Introduction

Parkinson's disease (PD)-associated freezing of gait (FoG) (PDFoG) refers to episodes where patients feel the urge to move but experience temporary immobility or markedly shortened steps. This leads to frequent falls and, eventually, the loss of walking ability, severely affecting patient quality of life and life expectancy. Despite its clinical importance, the neural mechanisms underlying PDFoG remain unclear.

Methods

This study sought to characterize abnormal neural activity in PDFoG by assessing regional brain activity using ALFF, fALFF, PerAF, and wavelet-ALFF across three frequency bands (conventional, slow-5, and slow-4). PDFoG patients were compared to PD patients without FoG (PDnFoG) and healthy controls. Clinical evaluations included standard assessment

SUBMITTER: Li X 

PROVIDER: S-EPMC12267242 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature