Age-dependent integration of cortical progenitors transplanted at CSF-neurogenic niche interface.

ABSTRACT: There has been renewed interest in neural transplantation of cells and tissues for brain repair. Recent studies have demonstrated the ability of transplanted neural precursor cells and in vitro grown organoids to mature and locally integrate into host brain circuitry. Most studies have focused on how the transplant behaves and functions after the procedure, but the extent to which the host brain can properly innervate the transplant, particularly in the context of aging, is largely unexplored. Here we report that transplantation of rat embryonic cortical precursor cells into the cerebrospinal fluid-subventricular zone (CSF-SVZ) interface of adult rat brains generates a brain-like tissue (BLT) at an ectopic site. This model allows for the assessment of precursor cell development, cel

SUBMITTER: Greene G 

PROVIDER: S-EPMC12267260 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature