Current perspectives and trends in colorectal cancer and cancer-associated fibroblasts: a review and bibliometric analysis.

ABSTRACT:

Background

Cancer-associated fibrocytes (CAFs), a key component of the tumour microenvironment, are marked by their heterogeneity. They also exhibit a high degree of plasticity. In the last two decades there has been a strong association established between CAFs and colorectal carcinoma (CRC). However, there are no comprehensive statistics on CRC or CAFs, and the potential directions for research.

Methods

The study performed a literature review spanning from January 1, 2004, to March 27, 2025, within the Web of Science Core Collection Database. VOSviewer and CiteSpace software were used to perform bibliometric analysis and visualization. Microsoft Excel and R was also utilized.

Results

The analysis included 1145 articles. The articles in question were published across

SUBMITTER: Qian C 

PROVIDER: S-EPMC12267271 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature