Exploring the relationship between dystonia and STN-DBS in Parkinson's disease: insights from a single-centre cohort.

ABSTRACT:

Introduction

Motor side effects may emerge after deep brain stimulation (DBS) of the subthalamic nucleus (STN) in Parkinson's disease (PD) patients. Out of 60 PD patients, we observed 16 patients displaying de novo dystonic symptoms after the implantation and 11 dystonic PD patients without benefit from the stimulation. We hypothesized that a common neural pathway may cause dystonia in both conditions. Our study aims to investigate the clinical and connectivity substrates of dystonia after STN-DBS.

Methods

We divided our cohort into four groups: 16 patients displaying dystonia after STN-DBS, 11 patients with previously known dystonia not improving after surgery, 14 patients with dystonic symptoms relieved by the stimulation and 19 controls who never experienced dystonia. MAN

SUBMITTER: Remore LG 

PROVIDER: S-EPMC12267303 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature