Time-varying association between blood pressure and malignant brain edema after large hemispheric infarction: a prospective cohort study.

ABSTRACT:

Aim

To investigate the time-varying association between blood pressure (BP) and malignant brain edema (MBE) risk after large hemispheric infarction (LHI).

Methods

We prospectively enrolled LHI patients (CT hypodensity > 1/3 middle cerebral artery territory within 6 h or > 1/2 within 6-48 h of onset) from registry cohort. BP was recorded hourly and analyzed for 24 h and in two 12-hour epochs after onset: 1-12 h and 13-24 h. MBE was defined as neurological deterioration symptoms with midline shift ≥ 5 mm. Generalized estimating equation (GEE) compared BP patterns by MBE occurrence. Logistic regression and restricted cubic splines (RCS) assessed dose-response associations.

Results

Among 414 included LHI patients (mean age 69 ± 14y, median onset-to-admission interval 3 h

SUBMITTER: Song X 

PROVIDER: S-EPMC12267317 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature