Abnormal neural circuits and altered brain network topological properties in patients with chronic unilateral vestibulopathy.

ABSTRACT:

Background

Chronic unilateral vestibulopathy (CUVP) is one of the most common causes of chronic dizziness/vertigo. The brain functional mechanisms of CUVP are currently unclear. The study aimed to clarify changes in brain topological properties and subnetwork functional connectivity in CUVP patients, elucidating the neural mechanisms behind their poor dynamic compensation.

Methods

A total of 44 participants were included (22 CUVP patients and 22 age- and sex-matched healthy controls). Resting-state functional MRI was performed on all subjects. Network-Based Statistics (NBS) analysis was conducted to identify abnormal neural circuits in CUVP. Graph-theoretical analysis (GTA) was performed to elucidate changes in brain network topological properties. Correlation analysis was c

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12267322 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature