Association of heel bone mineral density with incident dementia among ageing adults: a population-based study from the UK Biobank.

ABSTRACT:

Background

Osteoporosis and dementia are two common disorders mainly affecting ageing population, and heel estimated bone mineral density (eBMD) measured by quantitative ultrasound (QUS) has been demonstrated to be a reliable and non-invasive method for assessing skeletal health. The aim of this study is to determine the association between eBMD and incident dementia in older adults.

Methods

This retrospective cohort study employs UK Biobank data of 131,030 adults aged ≥ 60 years without dementia at baseline. Cox proportional-hazards models were used to investigate the association between eBMD and incident dementia, with the C-index evaluating the discriminative potential of eBMD.

Results

Among participants (52.1% women, median [IQR] age was 64 [62-66] years), there w

SUBMITTER: Lu J 

PROVIDER: S-EPMC12267336 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature