The effect of copper on the antifungal activity of polyethyleneimines against quiescent conidia and germlings of Aspergillus nidulans.

ABSTRACT: The increase in the number of immunocompromised individuals combined with the severity of fungal infections in the general population has contributed to a significant increase in opportunistic fungal infections, which are often associated with high mortality rates. Although effective, existing antifungal drugs operate via a narrow range of mechanisms, leading to the rapid development of resistance and they primarily target growing host cells. Therefore, the need to develop next-generation antifungal agents that function via a broad range of mechanisms and/or target dormant/quiescent cells is highly important. In the present study, we investigated the characteristics and potential antifungal properties of a series of copper-chelated hyperbranched polyethyleneimines (PEI-Cu) with various mol

SUBMITTER: Tsiourvas D 

PROVIDER: S-EPMC12267394 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature