Mechanically robust neuroprotective stent by sequential Mg ions release for ischemic stroke therapy.

ABSTRACT: Most acute ischemic stroke patients with large vessel occlusion require stent implantation post-thrombectomy for complete recanalization, yet they exhibit a high rate of poor prognosis due to ischemia-reperfusion injury. Thus, combining reperfusion therapy with neuroprotective treatment offers significant advantages. This study introduces a novel Mg²⁺ eluting stent by incorporating neuroprotective MgSO₄ particles into a PLCL (poly (l-lactide-co-ε-caprolactone)) substrate using 3D printing technology. A novel MgSO₄-particle/Mg²⁺-ions combined-mechanical reinforcement mechanism was introduced. Subsequently, the neuroprotective efficacy of the stents was validated through oxygen-glucose deprivation/reoxygenation-injured neuron cells in vitro and via

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12267439 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature