Injury-specific pathways shape corneal nerve regeneration dynamics.

ABSTRACT: The cornea, a transparent tissue critical for clear vision, is uniquely characterized by a dense network of peripheral sensory nerves. This innervation not only enables sensation but also provides vital trophic support, ensuring corneal health and integrity. Damage or loss of these peripheral nerves leads to neurotrophic keratitis (NK), a debilitating condition that disrupts corneal healing and function, ultimately threatening vision. Remarkably similar to other peripheral neuropathies, NK arises from various injuries, diseases, or surgical interventions, yet its underlying regenerative mechanisms remain poorly understood, limiting effective treatment options. In this study, we investigated how corneal nerves regenerate following two different types of clinically relevant injuries-axotomy

SUBMITTER: Meneux L 

PROVIDER: S-EPMC12267522 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature