Effect of examined lymph node count on precise cancer-specific survival and effectiveness of adjuvant chemotherapy in resected colorectal cancer.

ABSTRACT: Substantial uncertainties remain regarding the establishment of an optimal examined lymph node (ELN) count for the comprehensive management of resectable colorectal cancer (CRC). The correlation of the ELN count with cancer-specific survival (CSS) and benefit from adjuvant chemotherapy (AC) in CRC was investigated using a large database, and the minimal threshold for ELN count in LN-negative patients was determined. The data on stage I to III CRC available in the SEER database (2010-2015) were analyzed to determine the correlation of ELN count with CSS and the benefit of AC using multivariable models. The series of odds ratios (ORs) and hazard ratios (HRs) were fitted using the join-point regression analysis. External validation was performed using the data of patients with stage I to III

SUBMITTER: Xiang R 

PROVIDER: S-EPMC12267557 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature