Photochemically synthesized gold nanoparticles conjugated with Boswellic acid inhibit alpha synuclein aggregation and delay fibrillation kinetics.

ABSTRACT: Neurodegenerative disorders are characterised by the gradual degeneration and death of neurons in distinct brain regions. In Parkinson's disease (PD), a key pathological hallmark is the aggregation of misfolded α-synuclein (α-Syn) into neurotoxic fibrils. Although natural products such as Boswellic acids (BAs) from Boswellia serrata exhibit therapeutic potential, their clinical application is limited by poor pharmacokinetic properties. To address this, we investigated BAs conjugated to gold nanoparticles (GNPs) to enhance bioavailability and therapeutic potential. Both covalent and noncovalent β-Boswellic acid to GNPs (GNP-BA) conjugates were synthesized and evaluated for their effects on α-Syn fibrillation in vitro. The spherical GNPs (< 32 nm) were successfully characterized via high-res

SUBMITTER: Gharb M 

PROVIDER: S-EPMC12267561 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature