A non-linear association between AST/ALT ratio and 28-day mortality in critically ill elderly: evidence from a multicenter study.

ABSTRACT: With the global aging population, the proportion of elderly patients in ICU continues to rise. The ratio of aspartate aminotransferase to alanine aminotransferase (AST/ALT) has been linked to unfavorable outcomes in several diseases, but its value in critically ill elderly patients remains unclear. Based on the eICU Collaborative Research Database, this study included 22,361 critically ill elderly patients aged ≥ 65 years. The connection between the AST/ALT ratio and 28-day all-cause mortality was assessed using multivariate Cox regression analysis, and generalized additive models were employed to investigate non-linear relationships. A mediation analysis was undertaken to investigate the mediating impact of white blood cell count (WBC). Following a comprehensive adjustment for confounding

SUBMITTER: Wang L 

PROVIDER: S-EPMC12267599 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature