Polygenic risk scores of rheumatoid arthritis associated with seropositivity and bone erosions in a Taiwanese population.

ABSTRACT: Polygenic risk scores (PRS) are widely used to estimate disease risks and predict clinical outcomes. However, ethnic differences exist worldwide. We aimed to use PRS for predicting the development of rheumatoid arthritis (RA) in a Taiwanese population and investigate whether PRS of RA may be associated with structural damage. PRS was calculated via GWAS data from 2,042 RA patients and 7,950 controls from the Taiwan Precision Medicine Initiative. LDpred2, PLINK, and PRSice-2 models were used to evaluate RA susceptibility via AUC. Clinical factors, including rheumatoid factor (RF), anti-citrullinated protein antibody (ACPA), medication, and bone erosion identified by X-ray or ultrasound, were compared across PRS quartiles. PRS derived from 97,396 SNPs via LDpred2 had the highest AUC. Partici

SUBMITTER: Wu TS 

PROVIDER: S-EPMC12267648 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature