Piperine Enhances Mitochondrial Biogenesis to Mitigate Stress in SH-SY5Y Neuroblastoma Cells.

ABSTRACT: Mitochondrial dysfunction plays a crucial role in neurodegenerative disorders. Enhancing mitochondrial biogenesis is a promising therapeutic strategy for mitigating mitochondrial damage. Piperine, a bioactive alkaloid from black pepper, the fruit of Piper nigrum L. in the family Piperaceae, has demonstrated neuroprotective effects against mitochondrial stress. However, its effects on mitochondrial health remain unclear. This study investigated the effects of piperine on mitochondrial dynamics in SH-SY5Y neuronal cells. Our findings suggest that piperine enhances mitochondrial biogenesis by upregulating peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) mRNA and translocase of outer mitochondrial membrane 20 (TOM20) protein expression. Additionally

SUBMITTER: Saikachain N 

PROVIDER: S-EPMC12267666 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature