The influence of deprivation on cortical development and psychotic symptoms in youth.

ABSTRACT:

Background

People with early-life experiences of deprivation are more likely to develop psychotic symptoms. While the mechanisms of this relationship are poorly understood, research suggests a role of cortical development.

Methods

In 6323 youth from the Adolescent Brain Cognitive Development study, we examined associations between total, material, interpersonal, cognitive and neighbourhood deprivation at age 9-11 years and psychotic-like experiences (PLEs) 2 years later. We then investigated whether associations were mediated by variation in cortical volume at baseline or rate of change from baseline to follow-up. Sex-specific effects were examined throughout.

Results

All deprivation measures were associated with greater PLEs. Most of these associations were partially

SUBMITTER: Thomas M 

PROVIDER: S-EPMC12267682 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature