Preoperative insulin resistance and stress response increase the risk of anastomotic leakage after colorectal cancer resection.

ABSTRACT: Insulin resistance and stress response are relatively prevalent among patients with colorectal cancer before surgery. This study aimed to explore the effects of these two disorders on the risk of anastomotic leakage after colorectal cancer surgery. Briefly, 503 patients with this type of cancer scheduled for surgery were enrolled. The study used the HOMA-IR to evaluate the patients' preoperative insulin resistance, collected blood samples to detect the preoperative levels of adrenaline and cortisol, and also adopted the State-Trait Anxiety Inventory and the Impact of Event Scale to assess the patients' psychological stress status. After performing the surgery, the study monitored the onset of anastomotic leakage within one month. Multivariable logistic regression was used for data analysis

SUBMITTER: Li S 

PROVIDER: S-EPMC12267693 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature