Immune cell diversity and regenerative markers reveal interactions among macrophages, rodlet cells, and stem cells in the kidney of Poecilia sphenops.

ABSTRACT: The kidneys of molly fish (Poecilia sphenops) exhibit complex immune and cellular activities, which are crucial for maintaining renal function and responding to environmental stressors. This study aimed to investigate the histological and immunohistochemical characteristics of immune cells, autophagy, and stem cell activity within the renal tissues of molly fish. Histological analysis revealed the presence of immune cells, including macrophages and granular leukocytes, concentrated around the renal corpuscles (RC) and renal tubules (RT). Additionally, numerous lymphocytes were observed surrounding the RC, and a notable presence of rodlet cells with a thick capsule and rodlet-like inclusions was detected around the RT. Immunohistochemical staining confirmed macrophage activity through CD68

SUBMITTER: Sayed RKA 

PROVIDER: S-EPMC12267737 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature