Causal links between iron status, mitochondrial function, and laryngeal and hypopharyngeal cancers: a Mendelian study.

ABSTRACT:

Background

This Mendelian randomization (MR) study aimed to investigate bidirectional causal relationships between genetically predicted iron homeostasis, mitochondrial function, and the risk of laryngeal and hypopharyngeal cancers.

Methods

Summary-level data were extracted from genome-wide association studies (GWAS) of iron status, mitochondrial function, laryngeal and hypopharyngeal cancers were analyzed. Two-sample MR analyses were performed using inverse variance weighted (IVW), weighted median, weighted mode, and MR-Egger regression. Sensitivity analyses incorporated MR-Egger intercept, MR-Pleiotropy RESidual Sum and Outlier (MR-PRESSO), Cochran's Q test, and leave-one-out validation.

Results

MR analysis identified a significant association between the mitochondr

SUBMITTER: Zhao J 

PROVIDER: S-EPMC12267800 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature