Anthropomorphic tissue-mimicking phantoms for oximetry validation in multispectral optical imaging.

ABSTRACT:

Significance

Optical imaging of blood oxygenation ( sO2 ) can be achieved based on the differential absorption spectra of oxy- and deoxyhemoglobin. A key challenge in realizing clinical validation of the sO2 biomarkers is the absence of reliable sO2 reference standards, including test objects.

Aim

To enable quantitative testing of multispectral imaging methods for assessment of sO2 by introducing anthropomorphic phantoms with appropriate tissue-mimicking optical properties.

Approach

We used the stable copolymer-in-oil base material to create physical anthropomorphic structures and optimized dyes to mimic the optical absorption of blood across a wide spectral range. Using 3D-printed phantom molds generated from a magnetic resonance image of a human forearm, we molded t

SUBMITTER: Dreher KK 

PROVIDER: S-EPMC12267859 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature