Cooling Blood and Detoxicating Formula Treats Psoriasis Through RHCG-Related Mechanisms.

ABSTRACT: This study explores the therapeutic potential of the cooling blood and detoxicating formula (CBDF) in the treatment of psoriasis, emphasizing its anti-inflammatory properties and its interaction with RHCG-related mechanisms. Psoriasis, a complex skin disorder characterized by abnormal keratinocyte proliferation and immune system dysregulation, remains challenging to treat effectively. Utilizing advanced techniques including network pharmacology, single-cell RNA sequencing (scRNA-seq), and spatial transcriptomics, this research identifies key active components in CBDF-quercetin and kaempferol-that influence critical inflammatory pathways. In experimental models, CBDF significantly alleviates psoriasis symptoms, reducing keratinocyte differentiation abnormalities and dendritic cell (DC) acti

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC12267955 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature