Sex differences in resting skeletal muscle and the acute and long-term response to endurance exercise in individuals with overweight and obesity.

ABSTRACT:

Objectives

Endurance exercise reduces the risk of metabolic diseases by improving skeletal muscle metabolism, particularly in individuals with overweight and obesity. As biological sex impacts glucose and fatty acid handling in skeletal muscle, we hypothesized sex differences at the transcriptomic and proteomic level in the acute response to exercise and after an 8-week exercise intervention.

Methods

We analyzed skeletal muscle biopsies from 25 sedentary subjects (16f/9 m) with overweight and obesity using transcriptomics and proteomics at baseline, after acute exercise, and following an 8-week endurance training program. Regulation of sex-specific differences was studied in primary myotubes from the donors.

Results

At baseline, differentially methylated CpG-sites pot

SUBMITTER: Dreher SI 

PROVIDER: S-EPMC12268009 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature