Promotive role of MBNL3 and PXN genes expressions with lncRNA PXN-AS1-L on gastric cancer.

ABSTRACT:

Background

Gastric cancer ranks fourth in both incidence and mortality worldwide. Several genes influence its genesis and progress.

Materials and methods

The expression of MBNL3, PXN genes, and lncRNA PXN-AS1-L was evaluated in gastric tissue samples from 75 gastric cancer patients and 75 controls by RT-PCR.

Results

MBNL3, PXN, and lncRNA PXN-AS1-L expressions were considerably raised among cancerous gastric tissue than in nearby normal tissue and normal tissue from controls (p < 0.001). LncRNA PXN-AS1-L and MBNL3 had the highest sensitivity (92.00 % and 90.67 %, respectively), with PXN sensitivity of 81.33 % for differentiation of the cancer tissue from adjacent normal tissue, while PXN and lncRNA PXN-AS1-L had the highest sensitivity (98.67 % and 92.00 %, respective

SUBMITTER: Abouelenin MAH 

PROVIDER: S-EPMC12268067 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature