Perturbation response scanning of drug-target networks: Drug repurposing for multiple sclerosis.

ABSTRACT: Combined with elastic network model (ENM), the perturbation response scanning (PRS) has emerged as a robust technique for pinpointing allosteric interactions within proteins. Here, we proposed the PRS analysis of drug-target networks (DTNs), which could provide a promising avenue in network medicine. We demonstrated the utility of the method by introducing a deep learning and network perturbation-based framework, for drug repurposing of multiple sclerosis (MS). First, the MS comorbidity network was constructed by performing a random walk with restart algorithm based on shared genes between MS and other diseases as seed nodes. Then, based on topological analysis and functional annotation, the neurotransmission module was identified as the "therapeutic module" of MS. Further, perturbation sc

SUBMITTER: Lu Y 

PROVIDER: S-EPMC12268079 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature