Seasonal Incidence of Human Metapneumovirus in High-Risk Adults With Medically Attended Acute Respiratory Illness in a Rural US Community.

ABSTRACT:

Background

The burden of human metapneumovirus (hMPV) among community-dwelling high-risk adults is understudied. We calculate the cumulative incidence of outpatient hMPV in high-risk adults, over five consecutive winter respiratory virus seasons (2015-2016 through 2019-2020), and describe clinical characteristics of their illnesses.

Methods

We conducted a retrospective analysis of data and respiratory specimens from adults ≥ 18 years old originally participating in a test-negative study of influenza vaccine effectiveness. We included adults with ≥ 1 high-risk condition in 2015-2016 through 2019-2020 seasons. Residual respiratory specimens were retested for hMPV using a multiplex viral panel. We calculated seasonal incidence using Poisson regression and population weighting,

SUBMITTER: Sundaram ME 

PROVIDER: S-EPMC12268109 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature