Beta burst-driven adaptive deep brain stimulation for gait impairment and freezing of gait in Parkinson's disease.

ABSTRACT: Freezing of gait is a debilitating symptom of Parkinson's disease that is often refractory to medication. Prolonged beta bursts within the subthalamic nucleus are associated with worse impairment and freezing, which are improved with deep brain stimulation. The goal of the study was to investigate the feasibility, safety and tolerability of beta burst-driven adaptive deep brain stimulation for gait impairment and freezing of gait in Parkinson's disease. Seven individuals with Parkinson's disease were implanted with the investigational Summit™ RC + S deep brain stimulation system (Medtronic, PLC, Dublin, Ireland). A PC-in-the-loop architecture adjusted stimulation in real-time based on beta burst durations in the subthalamic nucleus. A rigorous calibration procedure was employed to find par

SUBMITTER: Wilkins KB 

PROVIDER: S-EPMC12268161 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature