Gold nanoparticle-loaded macrophages enhance radiotherapy via immune remodeling in oral cancer.

ABSTRACT: Gold nanoparticles (GNPs) are promising radiosensitizers owing to their high atomic number, but their therapeutic efficacy is often limited by reticuloendothelial system (RES)-mediated clearance and poor tumor accumulation attributable to elevated interstitial fluid pressure. This study explored macrophage-mediated GNP delivery to enhance radiotherapy (RT) efficacy in oral cancer by leveraging the tumor-homing ability, immune plasticity, hypoxia tropism, and RES evasiveness of macrophages. Murine oral cancer cells (MCTQ1) and macrophages (RAW 264.7) were used. GNPs were synthesized using the Turkevich method, which were then assessed for radiosensitization using cell viability and colony formation assays. GNPs were radiolabeled with Iodine-131 (¹³¹I) using the chloramine-T metho

SUBMITTER: Chan HW 

PROVIDER: S-EPMC12268203 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature