Synthesis, characterization, antimicrobial activity and <i>in silico</i> study of pyridinium based ionic liquids.

ABSTRACT: A series of twenty-one pyridinium-based ionic liquids (ILs) was synthesized and thoroughly characterized using FTIR, NMR, UV-Vis spectroscopy, and melting point analysis. The ILs' antibacterial activity was assessed against Aspergillus niger and a panel of bacteria, both Gram-positive and Gram-negative. Notable antibacterial and antifungal properties were demonstrated by IL-10, IL-11, and IL-14 specifically. Several ILs also demonstrated effective Brønsted acidic catalysis for the Mannich process under mild, solvent-free circumstances. The biological activity of IL-19 and IL-21 was found to be correlated with their significant binding affinities to microbial protein targets, as demonstrated by molecular docking experiments. Selected ILs, especially IL-05 and IL-21, were found to be

SUBMITTER: Jahirul Islam M 

PROVIDER: S-EPMC12268257 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature