Comparative study of brain activity and functional connectivity in blepharospasm and blepharospasm-oromandibular dystonia.

ABSTRACT:

Background

The most common spread of blepharospasm (BSP) is to the oromandibular region, labeled as blepharospasm-oromandibular dystonia (BOM). We aimed to identify shared and different functional changes in BSP and BOM, trying to unveil the pathogenesis of these disorders and the mechanism of dystonic spread.

Materials and methods

This single center study recruited 16 BSP patients, 16 BOM patients and 20 healthy controls (HC). Clinical information and resting-state fMRI images were collected. Dynamic amplitude of low-frequency fluctuations (dALFF) was calculated using the sliding window method. Intergroup differences in static ALFF (sALFF) and dALFF were examined. Using dALFF results, seed-based static and dynamic functional connectivity (FC) were constructed to compare con

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12268265 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature