Structural and functional connectivity in tau mutation carriers: from presymptomatic to symptomatic frontotemporal dementia.

ABSTRACT:

Introduction

Microtubule-associated protein tau (MAPT) mutations cause frontotemporal dementia (FTD), characterised by behavioural, language, and motor impairments due to brain connectivity disruptions. We investigated structural and functional connectivity in 86 mutation carriers and 272 controls to map connectivity changes at different disease stages.

Methods

The CDR Dementia Staging Instrument plus National Alzheimer's Coordinating Center (NACC) Behaviour and Language domains (CDR plus NACC FTLD) stratified carriers into three groups: asymptomatic, prodromal, and symptomatic. We extracted measures of cortical thickness, white matter integrity, and functional connectivity, which were compared between each carrier group and controls using linear mixed models.

Results

SUBMITTER: Bouzigues A 

PROVIDER: S-EPMC12268314 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature