Fatty Acid Synthase regulates glucose and energy homeostasis via POMC neurons and adrenergic signals.

ABSTRACT:

Objectives

Hypothalamic Fatty Acid Synthase (FASN) plays a critical role in regulating energy balance by influencing food intake and body weight. This study aimed to investigate the neuronal mechanisms by which FASN impacts metabolism, focusing on its role in Pro-Opiomelanocortin (POMC) neurons.

Methods

We used transgenic mouse models with pre- or postnatal deletion of FASN specifically in POMC neurons in male mice. We evaluated changes in adiposity, glucose metabolism and metabolic parameters including food intake, energy expenditure and substrate utilization using metabolic chambers. Changes in neuronal activity were assessed using electrophysiology and further validated by optogenetic stimulation of POMC neurons. Additionally, the role of adrenergic signaling was examined

SUBMITTER: Leon-Mercado L 

PROVIDER: S-EPMC12268347 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature