Age and sex are associated with Alzheimer's disease neuropathology in Down syndrome.

ABSTRACT:

Introduction

This study investigates the association of age and biological sex with Alzheimer's disease (AD) neuropathology in Down syndrome (DS).

Methods

We examined the frontal/occipital cortex in people with DS (n = 14/13, 1-39 years), DS with AD (DSAD) neuropathology (n = 18/19, 42-61 years), late-onset AD (n = 15/16, 72-96 years), and age-matched controls (n = 50/47)(n = 156). The area occupied by AT8 and 6E10 immunolabeling, representing tangle and plaque loads, respectively, was used for segmented linear regression analyses.

Results

There was elevated neuropathology after age 35 in DSAD, with inflection points at ∼31 years (amyloid-β [Aβ]) and ∼28 (phosphorylated tau [p-tau]) in the frontal cortex and ∼36 years (both Aβ and p-tau) in the occipital cortex. Occip

SUBMITTER: Andrews EJ 

PROVIDER: S-EPMC12268376 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature