Development of Nanofiber Patch Formulation Containing Rutin Hydrate, In Vitro and In Vivo Evaluation.

ABSTRACT: Wound healing is a dynamic and multifactorial process that can be significantly impaired by oxidative stress, microbial infection, and chronic systemic conditions, often resulting in delayed recovery and poor tissue regeneration. This study investigates the use of rutin hydrate, a bioactive flavonoid with antioxidant and collagen-promoting effects, in electrospun nanofiber dressings to enhance wound repair outcomes. Electrospinning technology was used to fabricate nanofibers from poly-(vinyl alcohol) (PVA) and Eudragit L100, with optimized parameters determined via the Taguchi method. The nanofibers had average diameters of 258.371 nm (PVA) and 125.115 nm (Eudragit), with drug loading capacities of 78.735 ± 2.307 μg/mg per mass and 87.983 ± 2.055 μg/cm² per area (PVA); 76.833 ±

SUBMITTER: Ozer S 

PROVIDER: S-EPMC12268395 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature