Perfluorobutane Nanodroplets for the Selective Sensing and Range Verification of Carbon-Ion Radiotherapy: In Vitro Evaluation on Cells.

ABSTRACT: Range verification procedures are crucial in carbon-ion radiotherapy (CIRT) to avoid undesired exposure while harnessing the superior features in dose-depth distribution that allow for better biological effectiveness than other adopted radiotherapies. Recently, we have proposed an innovative approach to dosimetry and uncertainties measurement in CIRT by upgrading phase-change ultrasound contrast agents to function as injectable tracers for ionizing particle beams. We developed a stable formulation of superheated nanodroplets (NDs) made of a liquid perfluorobutane core encapsulated within a cross-linked poly-(vinyl alcohol) shell. The core vaporization is triggered by the high-linear energy transfer (LET) carbon ions at the Bragg peak, generating echogenic microbubbles, whereby the resultin

SUBMITTER: Toumia Y 

PROVIDER: S-EPMC12268400 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature