Deuterium- and Fluorine-18-Labeled Glutaminea PET Imaging Agent with Enhanced In Vivo Stability.

ABSTRACT: Deuterium and fluorine-18 dual-isotope-labeled fluoroglutamine, (2S,4R)-[4-¹⁸F-3,3,4-d ₃]-fluoroglutamine (4-[¹⁸F]-FGln-d ₃), was designed, synthesized, and biologically evaluated for its potential as a novel glutamine metabolic imaging agent with improved in vivo stability. The tetradeuterated homoserine 11 intermediate was first synthesized via a six-step synthetic pathway, including a chiral HPLC separation process. Next, (2S,4S)-tosylate precursor 14 was prepared following the reference-reported method, and 4-[¹⁸F]-FGln-d ₃ was successfully prepared using a semiautomated production process. After that, a head-to-head comparison of 4-[¹⁸F]-FGln-d

SUBMITTER: Akula HK 

PROVIDER: S-EPMC12268413 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature